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  1. Article ; Online: Osteonecrosis of the jaw in a patient under treatment of osteoporosis with oral bisphosphonate

    Marília A. Figueiredo / Frederico Buhatem Medeiros / Karem López Ortega

    Autopsy and Case Reports, Vol

    2021  Volume 11

    Abstract: Although uncommon in patients under oral therapy, bisphosphonate-related osteonecrosis of the jaw (BRONJ) can be a very severe issue. Early intervention with surgical resection should be the preferable method of treating any stage of the disease, ... ...

    Abstract Although uncommon in patients under oral therapy, bisphosphonate-related osteonecrosis of the jaw (BRONJ) can be a very severe issue. Early intervention with surgical resection should be the preferable method of treating any stage of the disease, resulting in better outcomes and decreasing the morbidity of this condition. A 77-year-old female patient attended the Special Care Dentistry Centre of the University of São Paulo Faculty of Dentistry (CAPE FOUSP) complaining mainly of “an exposed bone that appeared after tooth extraction performed six months earlier”. The patient was diagnosed with osteonecrosis associated with bisphosphonate (sodium ibandronate) and surgically treated with removal of bone sequestration and antibiotic therapy. The patient was followed up for six years (a total of 6 appointments), presenting good general health and no sign of bone exposure. Imaging findings showed no changes related to BRONJ either.
    Keywords Bisphosphonate-Related Osteonecrosis of the Jaw ; Ibandronic Acid ; Jaw ; Osteonecrosis ; Medicine ; R ; Internal medicine ; RC31-1245
    Subject code 616
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher University of São Paulo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Osteonecrosis of the jaw in a patient under treatment of osteoporosis with oral bisphosphonate.

    Figueiredo, Marília A / Medeiros, Frederico Buhatem / Ortega, Karem López

    Autopsy & case reports

    2020  Volume 11, Page(s) e2020186

    Abstract: Although uncommon in patients under oral therapy, bisphosphonate-related osteonecrosis of the jaw (BRONJ) can be a very severe issue. Early intervention with surgical resection should be the preferable method of treating any stage of the disease, ... ...

    Abstract Although uncommon in patients under oral therapy, bisphosphonate-related osteonecrosis of the jaw (BRONJ) can be a very severe issue. Early intervention with surgical resection should be the preferable method of treating any stage of the disease, resulting in better outcomes and decreasing the morbidity of this condition. A 77-year-old female patient attended the Special Care Dentistry Centre of the University of São Paulo Faculty of Dentistry (CAPE FOUSP) complaining mainly of "an exposed bone that appeared after tooth extraction performed six months earlier". The patient was diagnosed with osteonecrosis associated with bisphosphonate (sodium ibandronate) and surgically treated with removal of bone sequestration and antibiotic therapy. The patient was followed up for six years (a total of 6 appointments), presenting good general health and no sign of bone exposure. Imaging findings showed no changes related to BRONJ either.
    Language English
    Publishing date 2020-12-08
    Publishing country Brazil
    Document type Case Reports
    ZDB-ID 2815488-5
    ISSN 2236-1960
    ISSN 2236-1960
    DOI 10.4322/acr.2020.186
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  3. Article ; Online: Risk of Bleeding during Implant Surgery in Patients Taking Antithrombotics: A Systematic Review.

    Miziara, Luciano Nascimento Braga / Sendyk, Wilson Roberto / Ortega, Karem López / Gallottini, Marina / Sendyk, Daniel Isaac / Martins, Fabiana

    Seminars in thrombosis and hemostasis

    2021  Volume 47, Issue 6, Page(s) 702–708

    Abstract: The objective of this systematic review is to assess the risk of postoperative bleeding in oral surgery for implant placement in individuals taking antithrombotics (i.e., anticoagulants and/or antiplatelet agents). A literature search was performed in ... ...

    Abstract The objective of this systematic review is to assess the risk of postoperative bleeding in oral surgery for implant placement in individuals taking antithrombotics (i.e., anticoagulants and/or antiplatelet agents). A literature search was performed in PubMed (MEDLINE), Web of Science, Scopus, and EMBASE databases for articles published until August 2020, with no date restriction, and manually completed. We included prospective clinical studies that provided information regarding the presence of an experimental group (i.e., implant placement), a control group (patients not under treatment with antithrombotics), and a well-established protocol for evaluating bleeding. Meta-analysis determined the risk of bleeding during the placement of implants in antithrombotic-treated patients. Of the 756 potentially eligible articles, 5 were included in the analysis with 4 ranked as high and 1 as medium quality. Antithrombotic treatment comprised the following drug classes: (1) anticoagulants: vitamin K antagonists, (2) nonvitamin K antagonist oral anticoagulants, (3) low-molecular-weight heparin, and (4) antiplatelet agents (not specified). The results suggest that the risk of bleeding is not substantially higher in antithrombotic-treated patients (odds ratio = 2.19; 95% confidence interval: 0.88-5.44,
    MeSH term(s) Anticoagulants/adverse effects ; Fibrinolytic Agents/adverse effects ; Heparin, Low-Molecular-Weight ; Humans ; Postoperative Hemorrhage ; Prospective Studies
    Chemical Substances Anticoagulants ; Fibrinolytic Agents ; Heparin, Low-Molecular-Weight
    Language English
    Publishing date 2021-05-10
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 196901-8
    ISSN 1098-9064 ; 0094-6176
    ISSN (online) 1098-9064
    ISSN 0094-6176
    DOI 10.1055/s-0041-1722845
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  4. Article ; Online: Is 0.5% hydrogen peroxide effective against SARS-CoV-2?

    Ortega, Karem López / Rech, Bruna de Oliveira / Ferreira Costa, Andre Luiz / Perez Sayans, Mario / Braz-Silva, Paulo Henrique

    Oral diseases

    2020  Volume 28 Suppl 1, Page(s) 937–939

    MeSH term(s) COVID-19 ; Humans ; Hydrogen Peroxide ; Membrane Glycoproteins ; SARS-CoV-2
    Chemical Substances Membrane Glycoproteins ; Hydrogen Peroxide (BBX060AN9V)
    Keywords covid19
    Language English
    Publishing date 2020-07-06
    Publishing country Denmark
    Document type Letter ; Comment
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.13503
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  5. Article ; Online: Can children be affected by bisphosphonate-related osteonecrosis of the jaw? A systematic review.

    Duarte, Nathália Tuany / Rech, Bruna de Oliveira / Martins, Isabela Godoy / Franco, Juliana Bertoldi / Ortega, Karem Lopez

    International journal of oral and maxillofacial surgery

    2019  Volume 49, Issue 2, Page(s) 183–191

    Abstract: Knowledge of bisphosphonate-related osteonecrosis of the jaw (BRONJ) is mostly based on adult cases, however bisphosphonates are also currently recommended for different paediatric diseases resulting in osteoporosis. The aim of this study was to review ... ...

    Abstract Knowledge of bisphosphonate-related osteonecrosis of the jaw (BRONJ) is mostly based on adult cases, however bisphosphonates are also currently recommended for different paediatric diseases resulting in osteoporosis. The aim of this study was to review the literature on the risk of developing BRONJ in children and adolescents. The PubMed, LILACS, Web of Science, Scopus, and Cochrane databases were searched using the key words "bisphosphonates", "osteonecrosis", "jaw", and "children". Literature reviews, case reports, abstracts, theses, textbooks, and book chapters were excluded. Studies involving children and young adults (younger than 24 years of age) were included. A total of 56 publications were identified. After applying the eligibility criteria, only seven articles remained. Although no cases of osteonecrosis were identified, all studies had weaknesses such as a limited sample size or the absence of risk factors for the development of osteonecrosis. There is general consensus that this subject should be of concern and that further studies should be conducted before any definitive opinion is reached. It is believed that patients with secondary osteoporosis who use bisphosphonates continuously should be followed up during adulthood, since bone turnover decreases over the years.
    MeSH term(s) Adolescent ; Adult ; Bisphosphonate-Associated Osteonecrosis of the Jaw ; Bone Density Conservation Agents ; Child ; Diphosphonates ; Humans ; Osteonecrosis ; Osteoporosis ; Risk Factors ; Young Adult
    Chemical Substances Bone Density Conservation Agents ; Diphosphonates
    Language English
    Publishing date 2019-08-23
    Publishing country Denmark
    Document type Journal Article ; Systematic Review
    ZDB-ID 353721-3
    ISSN 1399-0020 ; 0901-5027
    ISSN (online) 1399-0020
    ISSN 0901-5027
    DOI 10.1016/j.ijom.2019.08.004
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  6. Article ; Online: Dental implants in patients seropositive for HIV: A 12-year follow-up study.

    Oliveira, Marcio A de / Pallos, Debora / Mecca, Fabio / Ortega, Karem López / Gallottini, Marina / Costa, Andre Luiz / Kim, Yeon Jung / Martins, Fabiana

    Journal of the American Dental Association (1939)

    2020  Volume 151, Issue 11, Page(s) 863–869

    Abstract: Background and overview: Patients seropositive HIV and AIDS represent a group of patients who experience longer longevity at the expense of effective therapies for infection control and related opportunistic diseases. However, the prolonged use of these ...

    Abstract Background and overview: Patients seropositive HIV and AIDS represent a group of patients who experience longer longevity at the expense of effective therapies for infection control and related opportunistic diseases. However, the prolonged use of these drugs is often associated with adverse events, which theoretically may influence dental management and the long-term stability of dental implants. The objective of this study was to prospectively evaluate a group of HIV-positive people from a previous study who had received dental implants for 12 years after oral rehabilitation and functional loading.
    Case description: Nine patients with a total of 18 implants participated in this study. Viral load was undetectable in 8 patients, with 1 who had 48 copies/milliliter. The cluster of differentiation 4 T lymphocyte count ranged from 227 through 1,000 cells/cubic millimeter, mean (standard deviation [SD]) 564 (271.13) cells/mm
    Conclusion and practical implications: These results suggest that dental implant treatment in HIV-positive patients achieved long-term survival, with a success rate comparable with that observed in healthy patients, indicating that implant rehabilitation is not a contraindication for HIV-positive patients.
    MeSH term(s) Alveolar Bone Loss ; Dental Implantation, Endosseous ; Dental Implants ; Dental Prosthesis Design ; Dental Prosthesis, Implant-Supported ; Dental Restoration Failure ; Follow-Up Studies ; HIV Infections/complications ; HIV Infections/drug therapy ; Humans ; Treatment Outcome
    Chemical Substances Dental Implants
    Language English
    Publishing date 2020-10-29
    Publishing country England
    Document type Case Reports
    ZDB-ID 220622-5
    ISSN 1943-4723 ; 0002-8177 ; 1048-6364
    ISSN (online) 1943-4723
    ISSN 0002-8177 ; 1048-6364
    DOI 10.1016/j.adaj.2020.07.026
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  7. Article ; Online: An interesting case of systemic lupus erythematosus in a patient with Moebius syndrome.

    Tenorio, Jefferson da Rocha / Figueiredo, Marília Andrade / Espindula, Aline / Gallottini, Marina / Ortega, Karem López

    Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry

    2018  Volume 38, Issue 2, Page(s) 112–115

    Abstract: Moebius' syndrome (MS) is characterized by a nonprogressive facial palsy associated with impairment in eye abduction, which can be uni- or bilateral. Some authors raise the possibility that patients with MS may suffer from social stigmatism due to their ... ...

    Abstract Moebius' syndrome (MS) is characterized by a nonprogressive facial palsy associated with impairment in eye abduction, which can be uni- or bilateral. Some authors raise the possibility that patients with MS may suffer from social stigmatism due to their facial dysmorphism and that constant teasing and bullying perpetrated by people in the same social circle are adjuvants in the development of low self-esteem, behavioral problems, and even psychiatric disorders. Psychological stress, anxiety, and depression are factors contributing to both development and impairment of autoimmune diseases, such as systemic lupus erythematosus (SLE). The objective of this work is to report the case of a patient with MS who developed SLE. In the present case report, we have emphasized the importance of both clinical dental examination and surgeon-dentist in the early diagnosis of systemic diseases by considering that these conditions can affect both syndromic and normoreactive patients.
    MeSH term(s) Adolescent ; Dental Care for Chronically Ill/methods ; Female ; Humans ; Lupus Erythematosus, Systemic/complications ; Mobius Syndrome/complications
    Language English
    Publishing date 2018-01-22
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 604118-8
    ISSN 1754-4505 ; 0275-1879
    ISSN (online) 1754-4505
    ISSN 0275-1879
    DOI 10.1111/scd.12272
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  8. Article: Is 0.5% hydrogen peroxide effective against SARS-CoV-2?

    Ortega, Karem López / Rech, Bruna de Oliveira / Ferreira Costa, Andre Luiz / Perez Sayans, Mario / Braz-Silva, Paulo Henrique

    Oral dis

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #608803
    Database COVID19

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  9. Article ; Online: Is 0.5% hydrogen peroxide effective against SARS‐CoV‐2?

    Ortega, Karem López / Rech, Bruna de Oliveira / Ferreira Costa, Andre Luiz / Perez Sayans, Mario / Braz‐Silva, Paulo Henrique

    Oral Diseases ; ISSN 1354-523X 1601-0825

    2020  

    Keywords Otorhinolaryngology ; General Dentistry ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1111/odi.13503
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  10. Article ; Online: Oral plasmablastic lymphoma as the first manifestation of AIDS.

    Vale, Daniela Assis do / Rogado, Carolina Martelli / Carvalho, Danielle Lima Corrêa de / Trierveiler, Marilia / Ortega, Karem López

    Anais brasileiros de dermatologia

    2017  Volume 92, Issue 5 Suppl 1, Page(s) 110–112

    Abstract: Plasmablastic lymphoma is a non-Hodgkin lymphoma characterized by its plasmacytic differentiation and predilection for the oral cavity. It is among the lymphomas most commonly associated with AIDS. This report details a case of a HIV-positive patient ... ...

    Abstract Plasmablastic lymphoma is a non-Hodgkin lymphoma characterized by its plasmacytic differentiation and predilection for the oral cavity. It is among the lymphomas most commonly associated with AIDS. This report details a case of a HIV-positive patient with a 1-month history of an exophytic mass in the gingival area of the upper left quadrant. The diagnosis of plasmablastic lymphoma was made based on its histopathological and immunophenotypical features. She was treated with chemotherapy followed by autologous hematopoietic stem cell transplantation. Despite complete resolution of the lesion, the patient died of cardiorespiratory arrest. This case illustrates plasmablastic lymphoma as the first clinical manifestation of AIDS, highlighting the importance of differentiating between a potentially malignant lesion and other pathologic processes.
    MeSH term(s) Acquired Immunodeficiency Syndrome/complications ; Acquired Immunodeficiency Syndrome/pathology ; Biopsy ; Female ; Humans ; Immunohistochemistry ; Lymphoma, AIDS-Related/pathology ; Lymphoma, AIDS-Related/therapy ; Middle Aged ; Mouth Neoplasms/pathology ; Mouth Neoplasms/therapy ; Mouth Neoplasms/virology ; Plasmablastic Lymphoma/pathology ; Plasmablastic Lymphoma/therapy ; Plasmablastic Lymphoma/virology
    Language English
    Publishing date 2017-06-02
    Publishing country Spain
    Document type Case Reports
    ZDB-ID 433655-0
    ISSN 1806-4841 ; 0365-0596
    ISSN (online) 1806-4841
    ISSN 0365-0596
    DOI 10.1590/abd1806-4841.20175417
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